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Screensize: 640 x 480 800 x 600 1024 x 768 1280 x 1024 UserName: Password: Format Mode: Basic  Help  Prompt  Format: Font Andale Mono Arial Arial Black Book Antiqua Century Gothic Comic Sans MS Courier New Georgia Impact Lucida Console Script MT Bold Stencil Tahoma Times New Roman Trebuchet MS Verdana   Size 1 2 3 4 5 6   Color Black Red Yellow Pink Green Orange Purple Blue Beige Brown Teal Navy Maroon LimeGreen Message: * HTML is OFF * Forum Code is ON Smilies [quote][i]Originally posted by Jeff_Browndyke[/i] [br]SPM appears to do a pitiful job coregistering anatomical to functionals collected via the 4T inverse spiral sequence. My problems are further magnified by ventricle size and generalized atrophy. Any thoughts on how to the tackle coregistration problems with the inverse spiral data? Anatomicals collected axial-oblique w/ .94 x .94 x 1.9 Functionals collected axial-oblique w/ 3.75 x 3.75 x 3.8 The plan is to eventually establish my own study-specific segmentation priors and apply the grey matter seg image to study-specific grey template normalization parameters to bring the functionals into the same space. This seems to be the most sensible method given the atrophy in the subject data and poor similarity with the demographics of the standard SPM templates. I've run through a few subjects and with standard coregistration flags (medium or light regularization), and I'm getting poor registration in the inferior occipital region, which then results in functional voxels in this region pushed down into cerebellum on the "coregistered" T1. Also, we're planning on running the same data w/ ROI analyses in native space, so good-to-better coregistration is going to be key. Any help or pointers would be most appreciated. Jeff [/quote]   Check here to include your profile signature. Check here to subscribe to this topic.